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A total of three % of active compound is excreted in urine as unchanged active substance. Tapentadol is On top of that metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 and to hydroxy tapentadol (2 %) by CYP2D6, which can be even further metabolised by conjugation. Thus, Lively substance metabolism mediated by cytochrome P450 proce